Notices by Erik Uden 🍑 (erikuden@mastodon.de), page 2

This was all a ploy

They're not ready 🥥🌴

The Lord Almighty has Spoken

The whitest man you know will fall out of a coconut tree 🥥🌴

If you can't give us Buttigeg, at least consider...

It's Kamencing 🥥🌴

ALL IN WHICH YOU LIVE AND WHAT CAME BEFORE YOU 🥥🌴

to distract from the fact Joe Biden was too senile to have a debate, The Guardian published an article claiming he has “good sex” with his wife. we're just supposed to pretend this didn't happen or...??

This is the most important election in our lifetime.

Harris/Harris 2024

I just love to post this here because in a year's time this will not make sense for anyone, yet in this brief moment we all understood.

It is true, I was the cat.

Oh Donny...

Stay poor, liberals

I feel J.D. Vance so much. Why is it allowed for fact checks to interfere with my so well constructed opinions?

First of all: enlightened centrism
Second of all: this shows you how little the rich need to care about politics, as their liberties are never on the line, in no election.

Rafah in 2023 vs. Rafah today.

It's important to note that before the destruction of Rafah, it was declared as a safezone by Israel. People across the entire country were told to flee here. Just three months into this conflict, over one million refugees had to make this city their new home.

As a result of this, the Rafah offensive was heavily criticized and Israel was ordered to stop, by the United States, the ICJ, the EU, all EU member states independently, China, Australia, Brazil... [Source]

Was there any response when this red line was crossed? No, there were no (economic) sanctions or otherwise political consequences, despite this obvious human rights violation.

The refugee encampment in Rafah was specifically bombed as well. [[Source](https://en.wikipedia.org/wiki/Tel_al-Sultan_attack]]

Just last month the official safezone was changed again, into a much smaller and much more crammed area. The entire population of Gaza should move again into a space that could never support them and that is subject to change any time.

Abiding by these human rights violating orders is suicide. However, high up from our ivory tower, people are criticizing refugees of a country for not fleeing when they were told to do so. Blaming the victims for their death, as they could've always fled. In a debate in Germany I was even told that by continuing to stay in their home, these people support Hamas.

I have no words for such a sentiment; refugees deserve support no matter what.

Tomorrow I will begin my participation in a medical study for the coming 19 days, testing a compound meant to treat multiple sklerosis. The specific compound name is RO7268489, which has been tested on 67 people in four previous studies as of yet. Both the FDA and the EMA have not approved this compound for a treatment.

Multiple sklerosis (MS) is caused when a protective coating on nerve cells (called myelin) is damaged in the central nervous system. A majority of approved drugs for the treatment of MS only influence the immune system in a way that relapse rates are reduced. The compound I am testing targets mechanisms in the brain responsible for worsening the disability, hence improving neurological functions.

My study is the fifth of this kind, ever, and is conducted in Groningen (Netherlands) by the ICON plc, a private healthcare intelligence and clinical research organization trading at the Nasdaq. The specific code for the study I'm participating in is PRA-RPUBIU40-0H13WG.

This compound is well tolerated in doses below 2mg, and due to unwanted side effects¹, the medical company sponsoring this study has decided to only continue testing below that dosis. Before this, it was tested until 6mg.

This part of the study is a “Multiple Ascending Dose” study, meaning it's supposed to evaluate safety and tolerability of the compound on the human body, as well as how quickly it gets digested, or how the human body generally responds to it (pharmacokinetics). Three groups of the compound are tested, each divided in two subgroups, one of which truly takes the compound, the other gets the placebo.

Group 1 gets 0.2mg of the compound
Group 2 gets 0.6mg of the compound
Group 3 gets 1.0mg of the compound

I am part of group 2 (b), which has 6 subjects taking the real drug, and two taking a placebo, meaning there's a 25% chance I'm simply drinking a glass of water for three weeks.

The research facility aims to also see the effects of the compound in the body (pharmacodynamics).

In order to do so, they will take cerebrospinal fluid samples through a lumbar puncture three times throughout the study.

If anything happens to me in the coming four years as a result of the effects of this compound or study, I have an insurance of 650,000 € (same amount is paid out to my family in the case of me dying).

Whatever I'll experience throughout the coming weeks is what multiple sklerosis patients will have to listen to as disclaimers whenever they'll take this medicine once it's approved.

I'll document everything I experience, both side effects and my overall thoughts, in this thread. That is for both my own sake, and maybe to document a piece of medical history, if it ever comes that far. Additionally, this may not be something you hear of a lot, hence I wanted to put it out there.

¹ Side effects include: anxiety attacks & increased heart rate, hyperventilation, motor unsteadiness, severe paranoia, trouble speaking, trouble completing sentences, trouble verbalizing thoughts and a feeling of loss of control (which lasted 3-5 days until full recovery), increased suicidal tendencies

112 years ago today #OTD