True story:
On my ASUS ROG Strix laptop with a fully updated Windows 11 and AMD Radeon graphics driver, #PathofExile2 defaults to the integrated graphics instead of my Radeon 6600M. I can't select it in-game. Trying to override that in Windows' "Graphics" settings results in the settings window crashing every time.
My #Garuda partition on the same laptop: boots up PoE2 using the dedicated GPU. No tweaks required.