"PyNGtuber" appears not to work well, which given its creator is hardly surprising, However, "PNGTuber-Remix" does. Moreover, while it may be developed by what appears to be a Tumblr furry (?), no tranny flags or pronouns in the bio is a positive sign.
Open Source (MIT License) and Linux binary provided, and it seems to work reasonably well. I've only scratched the surface with it so far, but I've managed to set up rudimentary darken/lighten, static/animated states toggled by mic volume, so it works and seems fit for purpose.