it's the Chick Tract "Most People Rejected His Message" meme again. This time, the Jesus sillhouette is replaced with Sayuri's pixellated avatar, who is saying "we need to horribly rip off more of Jack Chick's copyrighted art and messages for cheap memes, to which a man who has been photoshopped to have David W Daniels's face replies "Shut up!" They hated Sayuri because they told them the truth.
https://media.chitter.xyz/media_attachments/files/113/035/769/908/458/209/original/dc09c5e826bec327.png