Notices by Eric Topol (erictopol@mstdn.social)

We knew about loss of smell and taste with Covid infections. A nationwide report from S Korea found a 3.5-fold increase in hearing loss among young adults
https://thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00338-9/fulltext

The highly pro-inflammatory and pervasive microplastics and nanoplastics: previously found in arteries and associated with increased in heart attacks and strokes, now in all human testes that were assessed.

https://erictopol.substack.com/p/theres-plastic-in-my-plaque

https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfae060/7673133?redirectedFrom=fulltext&login=false#no-access-

Nice profile of Peter Hotez
and his work in this week's Lancet

https://thelancet.com/journals/lancet/article/PIIS0140-6736(24)00007-2/fulltext

T-cell engineering therapy (CAR-T) may have cured 15 people with 3 different autoimmune diseases (Lupus, SS, IIM).

In drug-free remission, ~2 years after treatment

https://www.nature.com/articles/d41586-023-03968-6

The next SARS-CoV-2 variant up is JN.1, a BA.2.86 add on, which differs considerably cf HV.1 (current US lead), EF.5.1, XBB.1.5 (booster target). It's likely to further challenge our immune response (spike mutation map below) and main results from Yunlong Cao's lab

We've seen a cluster of advances in medical #AI in recent days, from randomized trials to making difficult diagnoses. The new Ground Truths gets into it all.

https://erictopol.substack.com/p/all-eyes-on-medical-ai

Our comprehensive review of #LongCovid was just published today
access: https://rdcu.be/c3m45
The phenomenal work of Hannah David, Lisa McCorkell, and Julia Moore-Vogel https://www.nature.com/articles/s41579-022-00846-2